By Lokesh Bhattacharyya, Jeffrey S. Rohrer
It is a entire resource of knowledge at the program of ion chromatography (IC) within the research of pharmaceutical medicinal drugs and biologicals. This ebook, with members from academia, pharma, the biotech undefined, and tool production, provides different views, adventure, and services of the concept leaders of IC in a complete demeanour. It explores capability IC purposes in numerous points of product improvement and quality controls checking out. additionally, an appendix part offers details on severe actual and chromatographic parameters concerning IC and data on present brands of IC structures, columns, and different components.Content:
Chapter 1 Ion Chromatography—Principles and purposes (pages 1–21): Lokesh Bhattacharyya
Chapter 2 Retention methods in Ion?Exclusion Chromatography: a brand new standpoint (pages 23–47): Milko Novic and Paul R. Haddad
Chapter three Pulsed Electrochemical Detection in Ion Chromatography (pages 49–90): William R. Lacourse
Chapter four Suppressor layout and Detection for Ion Chromatography (pages 91–105): Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin and Christopher Pohl
Chapter five Modelling and Optimization of Ion Chromatographic Separations of Pharmaceutically correct natural Ions (pages 107–133): Philip Zakaria, Greg Dicinoski, Melissa Hanna?Brown and Paul R. Haddad
Chapter 6 Ion Chromatography in Pharmaceutical Drug research (pages 135–157): Lokesh Bhattacharyya
Chapter 7 research for Impurities by means of Ion Chromatography (pages 159–174): Shreekant V. Karmarkar
Chapter eight Ion Chromatography research of Aminoglycoside Antibiotics (pages 175–192): Valoran P. Hanko and Jeffrey S. Rohrer
Chapter nine Use of Cation?Exchange Ion Chromatography within the research of prescribed drugs (pages 193–220): Christopher Pohl, Maria Rey and Rosanne Slingsby
Chapter eleven excessive functionality Ion Chromatographic research of Cholinergic Compounds: Carbachol and Bethanechol, and linked Degradation items (pages 237–245): David Trowbridge
Chapter 12 Ion Chromatographic research of prescribed drugs for Authenticity and Adulteration (pages 247–257): David S. Jackson
Chapter thirteen Ion Chromatography of Drug Product Counter?Ions and different Ions in Drug items (pages 259–269): Brian M. De Borba and Jeffrey S. Rohrer
Chapter 14 pattern guidance thoughts in Ion Chromatography for Pharmaceutical functions (pages 271–283): Jay Gandhi
Chapter 15 Validation of Ion Chromatographic tools (pages 285–308): Shreekant V. Karmarkar
Chapter sixteen Pharmacopeial functions of Ion Chromatography (pages 309–320): Ravi Ravichandran
Chapter 10 accomplished methods for size of lively Pharmaceutical parts, Counter?Ions, and Excipients utilizing HPLC with Charged Aerosol Detection (pages 221–236): Christopher Crafts, Bruce Bailey, Paul Gamache, Xiaodong Liu and Ian Acworth
Chapter 17 Glycan research by way of excessive functionality Anion alternate Chromatography with Pulsed Amperometric Detection (pages 321–338): Lokesh Bhattacharyya
Chapter 18 Monosaccharide research of Glycoproteins through High?Performance Anion?Exchange Chromatography with Pulsed Amperometric Detection (pages 339–350): Jeffrey S. Rohrer
Chapter 19 Two?Dimensional Ion Chromatography for Simultaneous choice of Amino Acids and Carbohydrates (pages 351–364): Petr Jandik and Jun Cheng
Chapter 20 tracking Protein N?Glycosylation Consistency utilizing HPAEC?PAD (pages 365–377): Carl Grey
Chapter 21 Oligosaccharide research through High?Performance Anion?Exchange Chromatography Hyphenated to built-in Pulsed Amperometric Detection and On?Line Ion?Trap Mass Spectrometry (pages 379–391): Cees Bruggink
Chapter 22 functions of Ion Chromatography in organic Product Analyses (pages 393–421): Alfred V. Del Grosso and Brandon Duong
Chapter 23 excessive functionality Anion?Exchange Chromatography with Pulsed Amperometric Detection (HPAEC?PAD) research of GBS Glycoconjugate Vaccines: From Fermentation to ultimate Product (pages 423–434): Stefano Ricci, Barbara Fabbri, Sara Giannini, Silvia Bernardini, Marcello Morelli and Sandro D'Ascenzi
Chapter 24 balance reports and Characterization of Meningococcal A, C, Y, and W135 Glycoconjugate Vaccine (pages 435–447): Valeria Carinci, Alberto Bernardini, Cristiana Campa, Claudia Magagnoli, Francesca Beccai and Sandro D'Ascenzi
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Extra info for Applications of Ion Chromatography for Pharmaceutical and Biological Products
LC-GC 1987;5: 261–266. 25. Papadoyannis IN, Samanidou VF. Encyclopedia of Chromatography, Marcel, New York: Dekker; 2001. p 455–457. 26. Tanaka K, Haddad PR. Ion exclusion chromatography: liquid chromatography. In: Wilson ID, Adlard ER, Cooke M, Poole CF, editors. Encyclopedia of Separation Science, San Diego: Academic Press; 2000. p 3193–3201. 27. Ng KL, Paul B, Haddad PR, Tanaka K. Retention modeling of electrostatic and adsorption effects of aliphatic and aromatic carboxylic acids in ion-exclusion chromatography.
Chen ZL, Tang C, Xu J. Non-suppressed conductivity and indirect UV detection of carboxylic acids in environmental samples by ion-exclusion chromatography using 2,6-pyridinedicarboxylic acidic eluent. J. Chromatogr. A 1999;859:173–181. 3 PULSED ELECTROCHEMICAL DETECTION IN ION CHROMATOGRAPHY William R. 1 INTRODUCTION The ﬁrst commercial electrochemical detector (EC) for high performance liquid chromatography (HPLC) was introduced in 1974, and over the past several decades its popularity, breadth, and application have grown signiﬁcantly.
4 CONSIDERATION OF OTHER PHENOMENA IN IEC The discussion thus far has focused on the conventional form of IEC which involves the separation of weakly acidic analytes on sulfonated polymeric cation-exchangers using acidic eluents. However, there are ways in which IEC is utilized and other aspects of the technique that need to be explained by the proposed mechanism outlined in Section 3 above. These include an evaluation of the peak shapes observed in IEC, the simultaneous separation of anions and cations by IEC using a carboxylate weak cation-exchange column, and the use of indirect UV-Vis detection in IEC.